sabato, marzo 08, 2014

From Scourge to Cure: Viruses Versus Cancer

See on Scoop.itCuriosopernatura





Viruses versus cancer. Who’s your money on?

With [oncolytic viruses] OV cancer therapeutics entering advanced-stage trials and showing clinical efficacy, strategies that further broaden OV targeting and replication capacity to address the heterogeneous nature of tumours and their associated vascular and stromal architecture will be extremely useful. Since such heterogeneity not only exists between patients but also within a given tumour/patient, where the metabolism, signal transduction, and antiviral states of cancer cells can be variably abnormal and, therefore, variably support OV replication, combinatorial strategies will be essential to promoting reliable tumour control and regression. Finally, continued efforts to identify components innate to the complex tumour microenvironment that promote OV replication will be critical to further improving OVs and developing new engineering strategies.




See on http://bit.ly/PcJVpW


Flu viruses derive from a global selective sweep in the 1870s

See on Scoop.itCuriosopernatura





A single event seems to have set the stage for all pandemics since.



See on arstechnica.com


Giant virus resurrected from 30,000-year-old ice

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Largest virus yet discovered hints at viral diversity trapped in permafrost.



See on www.nature.com


Comparing Genome Editing Technologies

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ZFN, TALEN, and CRISPR/Cas systems help scientists dissect

the vast amount of information accumulated through

the Genomic Revolution.



See on www.genengnews.com


Nanotechnology needle arrays for drug delivery

See on Scoop.itCuriosopernatura



The ultimate goal of nanotechnology-enabled drug delivery, especially with regard to cancer therapy, is to ferry most of the administered drug to the target, while eliminating the accumulation of the drug at any non-target tissues.

Nanomedicine applications with targeted nanoparticles are expected to revolutionize cancer therapy. The use of such nanoparticles to deliver therapeutic agents is currently being studied as a promising method by which drugs can be effectively targeted to specific cells in the body, such as tumor cells.




See on www.nanowerk.com


Scientists Create Genetically Modified Cells That Protect Against HIV

See on Scoop.itCuriosopernatura





The treatment is considered radical, and the results were drawn from a small scale human trial, but for the first time in medical history, researchers have boosted their patients’ ability to fight HIV by replacing some of their natural immune cells with genetically modified versions.



See on io9.com


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